MANAGEMENT OF DRUG EXTRAVASATIONS - …
Hyperosmotic Agents (>280 mOsmol/L) Ischemia Inducers. Direct Cellular Toxins. Nonantineoplastic Agents. Antineoplastic Agents. 1 In addition to the known vesicants, a number of other antineoplastic agents, not generally considered to be vesicants, have been associated with isolated reports of tissue damage following extravasation.